The minimum graduation requirements effective for Santa Fe High School graduates are as follows:
| Communication Arts | 5 units |
| Social Studies | 4 units |
| Mathematics | 3 units |
| Science | 3 units |
| Fine Arts | 2 units |
| Practical Arts | 2 units |
| Physical Education | 2 units |
| Health Education | 1/2 units |
| Personal Finance | 1/2 units |
| Electives | 13 units |
| Total | 35 units |
The District will accept courses offered through Missouri's K12 Virtual Instructional Program (MoVIP) as units of credit meeting state and local graduation requirements provided however the quantity and quality of completed student works meets standards applicable to the District's traditional program. (See Policy Virtual Instruction Program).
Eligible students as defined in Regulation 2525 may pursue a timely graduation from high school through the School Flex Program. Eligible students participating in the School Flex Program will be considered full-time students.